Article impregnated with skin-care formulations

ABSTRACT

An article is provided which may be in the form of an article of apparel, such as a glove, or a topical applicator for use in applying a therapeutic substance to the skin, which article is impregnated with the oil phase of a cream formulation. The oil phase impregnant is in the form of a non-oily solid which upon addition of water or moisture thereto is activated to form a cream.

I United States Patent 1 1 1 3,896,807

Buchalter July 29, 1975 [54] ARTICLE IMPREGNATED WITH 2,765,789 10/1956Schmierer 128/260 4 2,804,424 8/1957 Stirn et a1. 424/14 SKIN CAREFORMULATIONS 2,804,425 8/1957 Smith et a1..... 424/26 Inventor: GilbertBuchalter, 555 Mt. Prospect 3,328,259 6/1967 Anderson 424/28 Ave.,Newark, NJ. 07014 3,490,454 1/1970" Goldfarb et a1 128/285 [22] Filed:June 13, 1974 Primary Exammer-Aldnch F. Medbery 1 1 pp N05 478,924Attorney, Agent, or Firm-Lerner, David, Littenberg & Samuel [52] US. Cl.128/26]; 128/263; 424/16;

424/26; 42 /2 [57 ABSTRACT [51] Int. Cl A6lm 35/00 [58 Field of Search128/260, 261, 263, 8]; pmwsded wh'ch may be 1 424/28 1 6 26 l 4 art1c1eof apparel, such as a glove, or a top1ca1 applicator for use in applyinga therapeutic substance to the skin, which article is'impregnated withthe oil phase of [56] Reerences a cream formulation The oil phaseimpregnant is in UNITED STATES PATENTS the form of a non-oily solidwhich upon addition of 2,653,601 9/1953 Morrison 128/165 water ormoisture thereto is activated to form a 2,664,087 12 1953 Lewis cream2,671,446 3/1954 Mann 2,685,086 8/1954 Henry 128/260 X 26 Claims, N0Drawings ARTICLE IMPREGNATED WITH SKIN-CARE FORMULATIONS FIELD OF THEINVENTION The 'present invention relates to an article such as a pieceof apparel or an applicator pad, impregnated with the oil phase of acream formulation which upon the addition of moisture thereto forms askin-soothing cream.

BACKGROUND OF THE INVENTION The therapeutic effect which creams or oilshave on the skin is unquestioned. For example, use of hand creams orfacial creams are essentially in treating and- /or preventing chappingor chafing of the skin.

The prior art is replete with articles of apparel and applicator padsfor use in applying therapeutic creams, lotions or oils to the skin. Forexample, U.S. Pat. No. 2,501,565 discloses a hand mitten impregnatedwith a cream such as lanolin and lemon oil; U.S. Pat. No. 2,916,036discloses a rubber glove, the lining of which is impregnated with anunguent material such as lanolin; other patents disclosing glovesimpregnated with creams include U.S. Pat. Nos. 3,116,732; 3,342,182;3,298,368; 3,384,083; and 3,499,446. Other articles of apparelimpregnated with various therapeutic cream or oil formulations aredisclosed in U.S. Pat. Nos. 3,354,884 (facial mask); 2,716,981 (facialmask); 2,664,087 (foot slipper); 3,489,884 (diapers); and 3,585,998(diaper liners).

Paper products, such as tissues and toilet tissues are knowwn to beimpregnated with therapeutic cream or oil formulations. For example,U.S. Pat. No. 302,073 discloses a toilet paper impregnated with anunctuous or oily material such as vaseline, glycerine, paraffin oranimal or vegetable oils. U.S. Pat. No. 1,687,643 discloses a toilettissue coated with a creaam which coating may e covered with a layer ofparaffin to prevent the fingers from becoming soiled by the cream. U.S.Pat. No. 1,868,862 discloses a detergent towel impregnated with a soapcompound which may include glycerine. U.S. Pat. No. 2,032,645 disclosesan absorbent paper product containing a wetting agent to preserve thepaper against loss of absorbency. U.S. Pat. No. 2,944,931 discloses asanitary paper containing lanolin in the form of an aqueous emulsion.U.S. Pat. No. 3,264,188 discloses a sanitary impregnated skin wiper,such as toilet tissue, impregnated with an oily material and anemulsifying agent.

Patents disclosing applicator pads or cloths or paper impregnated withcreams or cream-like materials include U.S. Pat. Nos. 1,836,833;2,495,066; 2,702,780; 2,999,265; 3,624,224; and 3,129,811.

The articles or applicator paper or pads impregnated with cream orcream-like materials, disclosedin the afore-mentioned patents are quiteuseful for administering such creams to the skin. However, thesearticles and applicators have the same serious drawback, namely, thatthey are greasy or oily to the touch. They tend to stain oil-absorbentmaterials upon contact thereby losing the cream and ruining thematerials contacted therewith. Thus, they must be packaged with greatcare and at great expense. For example, the toilet tissue disclosed inU.S. Pat. No. 3,264,188 impregnated with an oil and an emulsifying agentmust be wrapped in oil-resistant paper to provide a non-stainingpackage.

U.S. Pat. No. 2,495,066 discloses a dusting and polishing paperimpregnated with a stable oil-in-waater emulsion, which comprises anon-drying oil and one or more emulsifying or surface active agents anda flexibilizing or plasticizing agent. The above ingredients are appliedto the paper as an aqueous emulsion and the paper is then dried oversteam rolls. The result is that the so impregnated paper is somewhattacky or sticky because some of the water of the aqueous emulsion hasnot been driven off by the heating over the steam rolls and resulted inemulsification.

STATEMENT OF THE INVENTION In accordance with the present invention,there is provided an article such as an article of apparel or a creamapplicator which is impregnated with the oil phase of a creamformulation, in the form of a non-oily non-tacky solid, and which uponthe addition of water or moisture thereto forms a therapeutic skincream. The article of the invention is not greasy or oily to the touchand need not be packaged in oil resistant paper or other oil resistantpackaging material and thus overcomes the afore-mentioned disadvantagesassociated with creams or cream-like or oily materials. Furthermore, thetherapeutic composition or oil-phase carried by the articles of theinvention is capable of controlled emulsion and sustained release of anyother therapeutic substance or medicament present in said oil-phase,depending upon the type, melting point and amounts of oily materials andemulsifiers employed.

DETAILED DESCRIPTION OF THE INVENTION In accordance with one embodimentof the present invention, there is provided an article of apparel, suchas a glove, glove liner, facial mask, slipper, diaper, sanitary napkinand the like, which is to be worn by the user so that an inside portionof said article comes into direct contact with the users skin in thearea to which a therapeutic cream is to be applied. The article ofapparel of the invention generally comprises-an outerportion which isworn away from the skin and an inner portion which comes into directcontactwith the skin of the user, which inner portion is impregnatedwiththe oil phase of a cream formulation which upon addition of moisturethereto forms a cream. The oil phase, be-

fore addition of water thereto, is in the form of a dry non-oilynon-sticky solid atroom temperature, and I generally comprises an oilymaterial and one or more emulsifying agents and may include in addition,one or Q more emollients, dyes, perfumes and/or pharmaceuticals.

nated with an oil phase of a cream formulation to form a new and mostadvantageous hand care product. The

glove or a pair of such gloves or liners maybe employed by themselves oras a separate liner under rubber gloves, under dress gloves, under workgloves or j gardening gloves. Furthermore, the 'glov esmay'l'beincorporated as permanent'liners intoany of 'the'afore gloves are wornwhile working, for examplefisu'ch'as rubber gloves worn during thewashing of dishes, floors and the like, the moisture and heat producedby per- Where the article of the invention comprises 'a glove I or gloveliner, the glove or glove liner may 'be inpregspiring of the hands, willbe sufficient to cause emulsification of a portion of the oil phase toform a therapeutic cream. Since the cream forms while the gloves arebeing worn, and perhaps while the wearer is working, the so-formed creamhas an opportunity to work its way into the pores of the skin to providebeneficial and therapeutic effects even after the gloves are removed.

Only a relatively small amount of emulsification is necessary to producea therapeutic amount of cream. The perspiration and heat generated bythe wearer will produce the necessary amount of moisture to form thedesired therapeutic amount of cream.

As indicated above, in accordance with the invention, the oil phase maybe impregnated into other articles which are employed in contact withthe skin, such as facial masks, slippers or shoe linings, diapers,diaper liners, sanitary napkins, dresses, pants and even bandages. Inall such applications the contact of the wearers skin will producesufficient moisture and heat to cause emulsification of a portion ofsaid oil phase.

Further in accordance with the present invention, there is provided anarticle for use in applying a therapeutic cream substance to the skinwhich article comprises a substrate impregnated with a therapeuticcomposition comprising the oil phase of a cream formulation in the formof a dry non-oily solid as described heretofore. Such substrate maycomprise paper or a paper product, such as a tissue, towel, toilettissue, woven and non-woven fabrics, and the like.

The oil phase which is in the form of a dry non-ily 'solid carried bythe article of the invention comprises from about 1 to about 99% andpreferably from about 30 to about 70 of an oily material and from about99 to about 1% and preferably from about 70 to about 30% of anemulsifier.

Examples of oily materials suitable for use herein include, but are notlimited to, mineral oil, petrolatum, paraffin, vegetable oil, such aslinseed oil, soya bean oil or cotton seed oil, various animal oils, suchas whale oil, lard oil, caster oil, olive oil, and isopropyl palmitate.

The emulsifying agents which may be employed herein cause emulsificationof an oil upon contact with the oil without the necessity of high speedmechanical agitation. Such emulsifiers include anionic emulsifiers,cationic emulsifiers, and non-ionic emulsifiers. Examples of suitableemulsifiers include, but are not limited to, cetyl alcohol, as well asany one of those classified in the following groups.

1. A long chain fatty acid partial ester of a hexitol anhydride whereinthe fatty acid has at least 6, preferably from 12 to 18, carbon atoms,including the long chain fatty acid partial esters of sorbitan, sorbide,mannitan and mannide and mixtures thereof. Examples of such esters aresorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate,sorbitan monooleate, and sorbitan trioleate, These compounds are sold byAtlas Powder Company under the trade names, respectively, Span Span 40",Span 60", Span 80, and Span 85". Additional examples of such esters aresorbide monolaurate, sorbide monomyristate, the mannide monoesters ofthe acids present in distilled coconut oil fatty acids, mannidemonostearates, and a mixture of mannitan monostearate, mannidemonostearate, mannitan distearate. These esters particularly themonoesters, may be prepared by the methods described in the US Pat. Nos.3,322,820, and 3,322,821,

to Kenneth R. Brown using as the fatty acid, for example, caproic,caprylic, capric, lauric, myristic, palmitic. oleic, linoleic,linolenic, ricinoleic, stearic, dihydroxy stearic, eleostearic and thelike or any mixture thereof, including the fatty acids derived fromanimal fats and oils and vegtable oils such as lard, sardine oil, whaleoil, menhaden oil, coconut oil, soya bean oil, corn oil, olive oil andthe like.

2. Polyoxyalkylene derivatives of any one or any mixture of theforegoing hexitol anhydride long chain fatty acid partial esters,particularly the polyoxyethylene derivatives. Examples of suchderivatives are polyoxyethylene derivative of sorbitan monolaurate,polyoxyethylene derivative of Sorbitan monopalmitate, polyoxyethylenederivative of sorbitan monostearate, polyoxyethylene derivative ofsorbitan trioleate. These polyoxyethylene derivatives are sold by AtlasPowder Company under the tradenames, respectively, Tween 20", Tween 40,Tween 60, Tween and Tween They are prepared, in general, by reacting along chain fatty acid partial ester of a hexitol anhydride with ethyleneoxide or other alkylene oxide in large molar excess. Thus, for example,Tween 80 is formed by reacting about 5 mols of ethylene oxide per mol ofsorbitan monooleate and Tween 85 is formed by reacting about 20 mols ofethylene oxide per mol of sorbitan trioleate.

3. Polyoxyalkylene derivatives of a glycol long chain fatty acidmonoester, particularly the glycol monoesters of fatty acids having atleast 12 carbon atoms such as those set forth above. Particularlyeffective derivatives are the polyoxyethylene derivatives formed byreacting a large molar excess of ethylene oxide with an ethylene,diethylene, propylene, butylene or triethylene, etc., glycol monoesterof a fatty acid having from 12 to 18 carbon atoms. The preferred onesare those formed by reacting 20, 25 and 30 mols, respectively, ofethylene oxide per mol of propylene glycol monostearate. They are soldby Atlas Powder Company under the tradenames, respectively, G-2 l 50",G-2 l 60"and G-2l70". The product G-2l50is most effective.

4. Soaps of aliphatic acids, alkyl aryl sulfonates, alkyl aryl polyethersulfonates, fatty alcohol sulfates, and sulfonated aliphatic compounds.

Examples of suitable anionic emulsifiers include all soaps, potassiumlaurate, triethanol amine stearate, sodium lauryl sulfate, alkylpolyoxyethylene sulfates, and dioctyl sodium sulfosuccinate.

Other examples of suitable emulsifiers are Neutronyx 600, Triton X-lOO,Ninol 979, and Ethofat 242/20. Others are available. The preferredemulsifier is Promulgen G or D (polyethylene glycol ether complex ofhigher fatty alcohols).

Ninols are trade-marked products of Ninol Laboratories, Chicago,Illinois, made in accordance with Kritchevsky US. Pat. No. 2,089,212.They are condensation products of one mole of aliphatic monocarboxylicacid with at least two moles of alkylolamine. The compounds are readilydispersible or soluble in water, are stable in mildly acid and alkalinemedia, and are effective in the presence of calcium and magnesium ions.

The higher fatty acids (six or more carbon atoms) are preferred for thealiphatic radical. One such compound is Ninol 979. It is l00% active,nonionic, pale amber liquid with a specific gravity of 1.00corresponding to the product of condensing lauric acid withdiethanolamine.

Ethofats are trade-marked products of Armour and Company, ChemicalDivision, Chicago, Illinois. They are a family of fat-derived nonionicsurface-active agents. They are polyoxyethylene-glycol esters of fattyacids.

They vary from fluid liquids to soft pastes depending upon length andsaturation of the fatty chain and the relative proportion of thepolyethylene glycol residue, which factors also control thesolubilities.

The polyethylene glycol employed for the material may have have amolecular weight from 220 to 2200. The compounds Neutronyx are a familyof trademarked materials made by Onyx Oil Chemical Company, Jersey City2, New Jersey. They are nonionic surface-active agents, functioning asdetergents, emulsifiers and dispersants. They vary from liquids tolowmelting wax-like solids, all dispersible in water. Being nonionicthey are compatible with cationic and other nonionic compounds, such asquaternary ammonium compounds. They are stable in mildly acid andalkaline solutions. Chemically, they are ethers the various kinds beingdesignated commercially by a number:

No. 330polyalkylether condensate of fatty acids No. 600-aromaticpolyglycol ether, and specifically phenyl ether with polyethylene glycolNo. 834polyalkyl ether condensate of fatty acids Neutronyx 600 ismiscible in all proportions in water, has specific gravity of about 1,and in a 1% solution in water a pH of 7.3.

The Tritons are trade-marked materials of Rohm and Haas, Philadelphia 5,Pa. They vary from nonionic, to cationic and anionic activity, and arestable in strong acid and alkaline solutions.

The oil phase described above may also include emollients such as acetyl alcohol, which also functions as a stiffening agent, propyleneglycol, glycerine, triethylene glycol, spermaceti or other waxes,perfumes and- /or pharmaceuticals, as well as film formers, deodorants,opacifiers, astrigents, solvents and the like. In addition, stabilizerscan be added to enhance the shelf life of the oil phase such hasnon-ionic surfactants, cellulose derivatives, protein and lecithin. Allof the above types of materials are known in the art as additives ofcream formulations.

The oil phase impregnated in the article of the invention upon theaddition of water thereto, forms a cream or a less viscous lotion. Ineffect, that portion of the oil phase which comes into contact withmoisture becomes emulsified. The phenomena can be described asmicroemulsificaton, that is emulsification of the oil phase at the pointof contact with moisture which point will be that portion of the usersskin which contacts the oil phase. Thus, complete emulsification of theentire oil phase impregnated in the article of the invention is avoidedwith the result that the oil phase impregnant is long lasting and is notexhausted after a single use. Furthermore, if a medicament orpharmaceutical is also incorporated into the oil phase, it will be usedup in amounts corresponding to the amount of oil phase emulsified at anyone time. Thus, the oil phase carrying the medicament or pharmaceuticalcan be characterized as a sustained release carrier. The length of timefor sustained release of the cream and medicament is regulated by themelting point of the finished solid oil phase formulation, and the easeof emulsification thereof which is controlled by the amount and type ofemulsifiers employed. Varying rates of emulsification will be desireddepending upon whether the oil phase is impregnated in an article ofapparel or an applicator for the cream formulation. For example, where apaper product or applicator is impregnated with the oil phase, a lowmelting point oil phase formulation will be desired since the paperproduct will probably be of the one time use-throw-away type, so thatrapid and total emulsification is effected during the single use. Withthis type of product, it is preferred to employ an oily material whichis liquid at room temperature as opposed to paraffin or petrolatum.

One of the essential features of the article of the invention is thatthe oil phase impregnated therein is a dry non-oil non-greasy solid atroom temperature. The formulation of such an oil phase impregnant canonly be obtained by impregnating the-article or substrate with anon-aqueous homogeneous liquid mixture of the components of the oilphase, such as by spraying the liquid mixture onto the article orsubstrate or dipping the article or substrate into the liquid oil phaseuntil a desired amount is absorbed therein. Thereafter the articlehaving the oil phase impregnated therein is cooled to cause the oilphase to solidify and form a non-oily dry solid at room temperature.

Generally, in forming the homogeneous liquid mixture forming the oilphase, it will be necessary to heat the components above the meltingpoint of the highest melting component in the mixture so that all solidsare reduced to liquid form. This can also be accomplished by mixing withthe components of the oil phase nonaqueous solvents, such as acetone,chloroform, trichloroethylene, xylene, xylol, as well as other ketones,chlorinated hydrocarbons and aromatic solvents, with or without heating,to form a homogeneous liquid mixture of all components. The resultingliquid can then be applied to the article or substrate as describedabove and cooled to form a solid oil phase which has a smooth,non-sticky almost slippery finish.

Where upon cooling and solidification of the oil phase, one or more ofthe solvents mentioned above does not fomi a solid, these solvents maybe easily removed from the remaining solids by, for example, wip ing orexpression.

The above process where-in a solvent is employed to cause completedissolution of the components of the oil phase is desirable where heatis not compatible with the article or substrate to be impregnated.Furthermore, heating is not essential where such solvents are employed.

It is essential that water not be present in the oil phase beforeemulsification is desired. If water is present during the formation ofthe homogeneous liquid mixture of the oil phase components, even upondrying over steam over steam rolls and the like, all of the water maynot be removed; the result is that upon cooling and attemptedsolidification of the oil phase components, a tacky sticky product isproduced.

The article or substrate treated with the homogeneous liquid mixture ofoil phase components will be impregnated or coated with such oil phasedepending upon the porosity or absorbability of such article orsubstrate.

The following are some of the specific applications of the presentinvention:

1. lmpregnation of the lining of rubber or plastic gloves.

a. Provides cosmetic hand care treatment by merely wearing gloves.

b. Provides lubrication for easier insertion of hands and removal ofgloves c. hot hand care treatment by placing hands in hot water such aswhen doing dishes.

2. impregnation of dress or work glove lining. Provides cold weatherhand care treatment and lubrication.

3. Impregnation of glove liner for winter sports such as skiing. inaddition to cold weather hand care treatment and lubrication for ease ofinsertion and removel, the impregnated liner forms an extremelyeffective thermal barrier.

4. Impregnation of diaper liners and sanitary napkin covers. To preventor eliminate chafing due to friction.

5. impregnation of tissues and towels, both woven and non-woven fabrics.

a. Cleansing b. Lubricating c. Softening d. Moisturizing e. ProtectingIn addition, articles or substrates impregnated with the dry non-aqueousoil phase will have long shelf life if kept in a dry cool place sincethe solid oil phase will not be actuated until addition of moisutrethereto.

The following examples represent preferred embodiments of the presentinvention.

EXAMPLE 1 About 40 g. light mineral oil, about 40 g. Promulgen- G (thatis polyethylene glycol ether complex of higher fatty alcohols producedby Robinson-Wagner) and about g. of cetyl alcohol are heated at atemperature of about 90C while mixing until all solids are dissolved anda homogeneous liquid mixture is formed.

A glove lining is dipped into the mixture for a few seconds untilsaturated. The glove lining is then removed and allowed to cool at roomtemperature. The resulting product is found to have a smooth,non-sticky, almost slippery finish comprising the oil phase of a creamformulation.

Where the so treated glove lining is employed as a linear for rubbergloves and the combination employed while washing dishes with hot water,it is found that the perspiration released by the hands causes a lightcream coating to form on the hands which is an effective barrier toprevent moisture evaporation from the hands.

EXAMPLE 2 The procedure of Example l is repeated except that an oilphase formulation comprising about g. of Promulgen G (described inExample I) is employed.

EXAMPLE 3 solvent mixture are allowed to dry until a dry non-oily solidoil phase is formed while the tissue remains soft and supple.

The tissue may be employed as a cleansing tissue so that uponapplication of moisture thereto the oil phase coating is emulsified toform a cleansing cream.

EXAMPLE 4 Following the procedure of Example 1, a tissue was impregnatedwith a homogeneous liquid mixture comprising 30 g. Tween and 50 g. ofheavy mineral oil. The resulting tissue remained soft and supple and maybe employed as a cleansing tissue so that upon application of moisturethereto the oil phase impregnated therein emulsifies to form cleansingcream.

EXAMPLE 5 Following the procedure of Example 1, a tissue was impregnatedwith a homogeneous liquid mixture comprising 30 g. SPAN 80, and 50 g.paraffin. The resulting tissue remained soft and supple and may beemployed as a cleansing tissue so that upon applicattion of moisturethereto the oil phase impregnated therein emulsifies to form a cleansingcream.

EXAMPLE 6 Following the procedure of Example 1, a tissue was impregnatedwith a homogeneous liquid mixture comprising 30 g. Span 80, 50 g.paraffin and 10 g. cetyl alcohol. The resulting tissue remained soft andsupple and may be employed as a cleansing tissue so that uponapplication of moisture thereto the oil phase impregnated thereinemulsifies to form a cleansing cream.

What is claimed is:

1. An article to place in contact with the body for use in applying acosmetic or therapeutic substance to the skin, comprising a substrateand a therapeutic or cosmetic composition carried by said substrate andcomprising the oil phase of a cream formulation, said oil phase being adry emulsifiable solid, which upon addition of moisture thereto forms anoil in water or water in oil emulsion.

2. The article of claim 1 wherein said oil phase comprises an oilymaterial and an emulsifier. 3. The article of claim 2 wherein said oilymaterial is selected from the group consisting of mineral oil, paraffin,petrolatum, vegetable oil, linseed oil, olive oil and isopropylpalmitate.

4. The article of claim 2 wherein said emulsifier is selected from thegroup consisting of cetyl alcohol, polyethylene glycol ether complexesof higher fatty alcohols, fatty acid soaps of organic bases selectedfrom the group consisting of triethanolamine oleate, triisopropyl aminelaurate, monoethyl amine stearate and diethyl amine palmitate, surfaceactive agents selected from the group consisting of long chain fattyacid partial esters of a hexitol anhydride, and a polyoxyalkylenederivative of a long chain fatty acid monoester of a glycol, wherein thefatty acid contains 6 to 18 carbons, soaps of aliphatic acids, alkylaryl sulfonates, alkyl aryl polyether sulfonates, fatty alcohol sulfatesand sulfonated aliphatic compounds.

5. The article of claim 2 wherein said oily material comprises mineraloil and said emulsifier comprises a polyethylene glycol ether complex ofhigher alcohols.

6. The article of claim 5 wherein said oil phase further includes cetylalcohol.

7. The article of claim 2 wherein said oil phase comprises, in additionone or more emollients, dyes, perfumes and/or pharmaceuticals.

8. The article of claim 1 wherein said substrate com prises a woven ornon-woven material.

9. The article of claim 1 wherein said substrate comprises a tissue.

10. The article of claim 1 wherein said substrate comprises a face mask.

11. The article of claim 1 wherein said substrate comprises a shoe.

12. The article of claim 1 wherein said substrate comprises a footslipper.

13. The article of claim 1 wherein said substrate comprises a diaper.

14. The article of claim 1 wherein said substrate comprises a bandage.

15. The article of claim 1 wherein said substrate comprises a glove.

16. The article of claim 1 wherein said substrate comprises a diaperliner.

17. The article of claim 1 wherein said substrate comprises a sanitarynapkin.

18. The article of claim 1 wherein said substrate is a paper tissue.

19. The article of claim 1 wherein said substrate is a towel.

20. The article of claim 1 wherein said substrate is a paper towel.

21. A method of manufacturing an article for use in Ill applying atherapeutic or cosmetic substance to the skin, comprising providing asubstrate and a therapeutic or cosmetic composition carried by saidsubstrate, said composition comprising the oil phase of a creamformulation in the form of a dry solid, said solid com-v prising an oilymaterial and one or more emulsifiers, wherein said therapeutic orcosmetic composition is formed by mixing together the oily material andemulsifiers while each material is in a liquid state to form anon-aqueous substantially homogeneous mixture, and while said mixture isin liquid form, applying the mixture to the substrate, and convertingthe mixture to a non-oily solid.

22. The method in accordance with claim 21 wherein the oily material andemulsifiers are heated to form an all liquid mixture.

23. The method in accordance with claim 22 wherein the liquid mixture isconverted to a solid by cooling.

24. The method in accordance with claim 21 wherein the oily material andemulsifiers are mixed together in the presence of a solvent causes theoily material and emulsifiers to form a liquid mixture.

25. The method in accordance with claim 24 wherein the liquid mixture ofthe oily material and emulsifiers is converted to a solid by removingthe solvent from the mixture.

26. The method of claim 22 wherein the oily material and emulsifiers areheated to at least the melting point of the highest melting component.

. UNITED STATES PATENT OFFICE CERTIFlCATE OF CORRECTLEON Patent No. ,807Dated July 29, 1975 Inventor(s) GILBERT BUCHALTER It is certified thaterror appears in the above-identified patent and that said LettersPatent are hereby corrected as shown below:

Column 1, Line 29 "3,489,884" should read: 3,489,148

Column 1, Line'38, "may e" should read: may be Column 2, Line 51, "Wherethe article of the invention" should read: Where the article of apparelof the invention Column 10, Line 21, insert "which" between "solvent"and "causes".

Signed and Scaled-this 0 eleventh Day of November 1975 [SEAL] Attest:

C RUTH c. MASON c. MARSHALL DANN Arresting Officer (mnmisximwr ofPatents um! Trademarks FORM PC4050 (10-59) UStOMM-fiC teams-1

1. AN ARTICLE TO PLACE IN CONTACT WITH THE BODY FOR USE IN APPLYING ACOSMETIC OR THERAPEUTIC SUBSTANCE TO THE SKIN, COMPRISING A SUBSTRATEAND A THERAPEUTIC OR COSMETIC COMPOSITION CARRIED BY SAID SUBSTRATE ANDCOMPRISING THE OIL PHASE OF A CREAM FORMULATION, SAID OUL PHASE BEING ADRY EMULSIFIABLE SOLID, WHICH UPON ADDITION OF MOISTURE THERETO FORMS ANOIL IN WATER OR WATER IN OIL EULSION.
 2. The article of claim 1 whereinsaid oil phase comprises an oily material and an emulsifier.
 3. Thearticle of claim 2 wherein said oily material is selected from the groupconsisting of mineral oil, paraffin, petrolatum, vegetable oil, linseedoil, olive oil and isopropyl palmitate.
 4. The article of claim 2wherein said emulsifier is selected from the group consisting of cetylalcohol, polyethylene glycol ether complexes of higher fatty alcohols,fatty acid soaps of organic bases selected from the group consisting oftriethanolamine oleate, triisopropyl amine laurate, monoethyl aminestearate and diethyl amine palmitate, surface active agents selectedfrom the group consisting of long chain fatty acid partial esters of ahexitol anhydride, and a polyoxyalkylene derivative of a long chainfatty acid monoester of a glycol, wherein the fatty acid contains 6 to18 carbons, Soaps of aliphatic acids, alkyl aryl sulfonates, alkyl arylpolyether sulfonates, fatty alcohol sulfates and sulfonated aliphaticcompounds.
 5. The article of claim 2 wherein said oily materialcomprises mineral oil and said emulsifier comprises a polyethyleneglycol ether complex of higher alcohols.
 6. The article of claim 5wherein said oil phase further includes cetyl alcohol.
 7. The article ofclaim 2 wherein said oil phase comprises, in addition one or moreemollients, dyes, perfumes and/or pharmaceuticals.
 8. The article ofclaim 1 wherein said substrate comprises a woven or non-woven material.9. The article of claim 1 wherein said substrate comprises a tissue. 10.The article of claim 1 wherein said substrate comprises a face mask. 11.The article of claim 1 wherein said substrate comprises a shoe.
 12. Thearticle of claim 1 wherein said substrate comprises a foot slipper. 13.The article of claim 1 wherein said substrate comprises a diaper. 14.The article of claim 1 wherein said substrate comprises a bandage. 15.The article of claim 1 wherein said substrate comprises a glove.
 16. Thearticle of claim 1 wherein said substrate comprises a diaper liner. 17.The article of claim 1 wherein said substrate comprises a sanitarynapkin.
 18. The article of claim 1 wherein said substrate is a papertissue.
 19. The article of claim 1 wherein said substrate is a towel.20. The article of claim 1 wherein said substrate is a paper towel. 21.A method of manufacturing an article for use in applying a therapeuticor cosmetic substance to the skin, comprising providing a substrate anda therapeutic or cosmetic composition carried by said substrate, saidcomposition comprising the oil phase of a cream formulation in the formof a dry solid, said solid comprising an oily material and one or moreemulsifiers, wherein said therapeutic or cosmetic composition is formedby mixing together the oily material and emulsifiers while each materialis in a liquid state to form a non-aqueous substantially homogeneousmixture, and while said mixture is in liquid form, applying the mixtureto the substrate, and converting the mixture to a non-oily solid. 22.The method in accordance with claim 21 wherein the oily material andemulsifiers are heated to form an all liquid mixture.
 23. The method inaccordance with claim 22 wherein the liquid mixture is converted to asolid by cooling.
 24. The method in accordance with claim 21 wherein theoily material and emulsifiers are mixed together in the presence of asolvent causes the oily material and emulsifiers to form a liquidmixture.
 25. The method in accordance with claim 24 wherein the liquidmixture of the oily material and emulsifiers is converted to a solid byremoving the solvent from the mixture.
 26. The method of claim 22wherein the oily material and emulsifiers are heated to at least themelting point of the highest melting component.